The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection
نویسندگان
چکیده
منابع مشابه
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation. Reliably high-quality iPSCs will be needed for future therapeutic applications. Here, we show that one ...
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15 صفحه اولthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2014
ISSN: 1934-5909
DOI: 10.1016/j.stem.2014.07.003